Principal Investigator

Dean Ho, Ph.D. (Director, N.1 Labs @NUS)

Contact: biedh AT nus.edu.sg

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Dr Dean Ho is currently Provost’s Chair Professor of Biomedical Engineering and Pharmacology, Director of the Singapore Institute for Neurotechnology (SINAPSE), and member of the Biomedical Institute for Global Health Research and Technology (BIGHEART) at the National University of Singapore.

Dr Ho and collaborators successfully developed and validated CURATE.AI, a powerful artificial intelligence technology platform based on the field of Phenotypic Personalized Medicine (PPM) to optimize clinical efficacy and safety for several combination therapy indications. He co-led the first in-human trial to personalize and optimize combination therapy for the entire duration of care, an unprecedented achievement. Specifically, his team partnered with leading surgeons to dynamically administer immunosuppressive therapies to prevent liver transplant rejection using CURATE.AI. CURATE.AI-treated patients dramatically outperformed control arm patients across every metric of comparison and were discharged nearly one month earlier compared to control patients (Science Translational Medicine, 2016). He also pioneered the development of nanodiamond platforms for the marked enhancement of efficacy and safety of drug delivery and imaging (Science Translational Medicine, 2011, 2013). Recently, Dr Ho initiated a first in-human clinical trial to validate a nanodiamond-biomaterial device for wound healing applications. Currently, Dr Ho is co-leading multiple oncologic combination therapy studies to dynamically modulate multi-drug regimens with CURATE.AI. These trials have resulted in completely halted disease progression and durable patient responses that far outperformed standard of care approaches.

 Dr Ho has appeared on the National Geographic Channel Program “Known Universe” to discuss his discoveries in nanodiamond drug delivery and imaging. His discoveries have been featured on CNN, The Economist, Forbes, Washington Post, NPR and other international news outlets. Dr Ho has served as the President of the Board of Directors of the Society for Laboratory Automation and Screening (SLAS), a 26,000+ member global drug development organization comprised of senior executives from the pharmaceutical and medical device sectors, as well as academic visionaries.

Dr Ho was recently named a Fulbright Scholar. He is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE) and Society for Laboratory Automation and Screening. He is also a recipient of the NSF CAREER Award, Wallace H. Coulter Foundation Translational Research Award, V Foundation for Cancer Research V Scholar Award, IADR William J. Gies Award, IADR Young Investigator Award, and Distinguished Young Alumnus award of the UCLA School of Engineering. Dr Ho is a co-founder of KYAN Therapeutics, and has previously advised venture funds and companies and in the areas of AI, digital medicine, and nanomedicine, among others.

 

Current Team Members

Theodore Kee: Head of Clinical Trials, CURATOR

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Peter Wang: Research Intern, CURATOR 

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Jordan Chong: Research Engineer, Head of AID.One

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FYP: Biomedical Engineering

Bjorn Betzler

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Collaborators

Edward Chow, Ph.D. (Principal Investigator and Assistant Professor, Cancer Science Institute of Singapore and Department of Pharmacology, National University of Singapore)

Masturah Bte Mohd Abdul Rashid, NUS

Nurrul Lissa Binti Abdullah, NUS

Tan Boon Toh, NUS

Ali Zarrinpar, M.D., Ph.D. (Associate Professor of Surgery, University of Florida)

 

Alumni

Dr. Houjin Huang

Dr. Erik Pierstorff

Dr. Dong-Keun Lee

Dr. Xue-Qing Zhang

Dr. Robert Lam

Dr. Sue Vin Kim

Dr. A. Nerisa Limansubroto

Prof. Ho-Joong Kim

Dr. Kangyi Zhang

Mark Chen

Albert Yen

Erik Robinson

Rafael Shimkunas

Han Man

Desiree Hsiou, UCLA

Darron Miya, UCLA

Michael Trieu, UCLA

Brian Wu, UCLA

Peter Wang, UCLA

Dr. Laura Moore, Northwestern and UCSF

...and countless other team members that made this journey possible.

Acknowledgements

Funding to the teams of Dr. Ho and Dr. Chow:

The V Foundation for Cancer Research

National Cancer Institute

National Center for Advancing Translational Sciences/National Institutes of Health

National Science Foundation

American Chemical Society

Wallace H. Coulter Foundation

Society for Laboratory Automation and Screening

Beckman Coulter Life Sciences

American Academy of Implant Dentistry Foundation (AAID/AAIDF)

National Medical Research Council, Singapore

National Research Foundation, Singapore